From The Writer's Almanac:
It was on this day in 1937, that Amelia Earhart was last heard from, somewhere over the Pacific. She and her navigator, Fred Noonan, had set off in May from Miami to fly around the world in a Lockheed Electra. She said, "I have a feeling that there is just about one more good flight left in my system, and I hope this trip is it."
They had completed all but about 7,000 miles of the trip when they landed in New Guinea. Maps of this part of the Pacific were inaccurate, and U.S. Coast Guard ships were in place to help guide them to their next stop, the tiny Howland Island. The weather was cloudy and rainy when they left New Guinea. At 7:42 a.m., Earhart communicated to the Coast Guard Cutter Itasca: "We must be on you, but we cannot see you. Fuel is running low. Been unable to reach you by radio. We are flying at 1,000 feet." Her last transmission, about an hour later, was "We are running north and south."